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Doxy-PEP Decision Making Tool

Clinical tool

First published:

March 2025

Last published:

March 2025

Overview

The Doxy-PEP Decision Making Tool supports prescribing doxycycline post-exposure prophylaxis (Doxy-PEP) to gay and bisexual men and transgender women at increased risk of syphilis. Suitable patients include those with recent syphilis or other STI diagnoses, periods of increased risk, or who wish to protect partners, provided there are no contraindications. Doxy-PEP should be part of a broader sexual health approach, including regular STI and HIV testing, vaccinations, and ongoing review of its need.

ASHM would like to thank Dr Nicholas Medland and the clinicians who advised on and reviewed this resource.

Suggested Professions

This is not an extensive list of professions, and other practitioners might benefit from this resource

Doctors