Performing hepatitis B serology following hepatitis B vaccination is not routinely indicated.
Post-vaccination screening, is recommended for:
- people at significant occupational risk (eg healthcare workers)
- people at risk of severe complications of hepatitis B disease (eg people who are immunocompromised, or those with pre-existing liver disease)
- people who may have a poor immune response (eg those with impaired renal function)
- sexual partners and household contacts of people living with hepatitis B.
This should be completed 4 weeks after the final vaccine dose.
If there is a current Anti-HBs level of < 10 mlU/mL 4–8 weeks following the final vaccine dose with a documented age-appropriate vaccine history, the person is deemed a non-responder. In this instance, you should follow the pathway provided here.
If a non-response persists, the patient should be informed of their immune status and advised to minimise exposures. If exposed, hepatitis B immunoglobulin can be given within 72 hours.