This document provides Australian (AU) Commentary on the AASLD-IDSA HCV Guidance: HCV in Children. Recommendations for testing, managing, and treating hepatitis C. Australian commentary has only been provided where needed in order to provide additional clarification or detail variations found in the Australian setting. Topics cover testing; transmission and prevention; monitoring and medical management; whom and when to treat among children and adolescents with HCV infection; and HCV antiviral therapy for children and adolescents.