Introduction
Doxy-PEP involves taking 200mg of doxycycline up to 72 hours after a sexual act to reduce the risk of bacterial sexually transmitted infections (STI). Among gay, bisexual, and other men who have sex with men (GBMSM), clinical trials of Doxy-PEP have shown significant reductions in syphilis (by 70–80%) and chlamydia (by 70–90%), and to a lesser degree, gonorrhoea (ineffective in some trials, or 50–55% reduction in other trials, due to varying levels of tetracycline resistance in gonococcal isolates in different populations).
However, uncertainty remains regarding unintended outcomes from Doxy-PEP. These may include harms to individuals taking Doxy-PEP, such as disruptions to their microbiome and increased antimicrobial resistance (AMR) in STIs and other organisms, and harms to the community through increased population-level AMR. As such, individuals who might benefit from Doxy-PEP need to be supported to weigh up the potential benefits versus the potential harms from using Doxy-PEP, while considering whether this STI prevention strategy is suitable for them in their current context, in addition to conventional STI prevention strategies such as condoms.
Evidence for the effectiveness of Doxy-PEP, and considerations around potential risks of Doxy-PEP, are described in detail in ASHM’s previously published interim position statement.
You can read the full consensus statement by visiting the Doxy-PEP Consensus Statement.
Discover our events calendar, featuring impactful health conferences and educational gatherings. Join health professionals, researchers, and community organisations in HIV, BBV, sexual health and other health fields. Explore our calendar to find engaging opportunities tailored to your interests and professional development.
ASHM Head Office – Sydney
Level 3, 160 Clarence Street
Sydney, NSW 2000
Tel: (+61) 02 8204 0700
Fax: (+61) 02 8204 0782
ASHM acknowledges the Traditional Owners of Country across the various lands on which our staff live and work. We recognise their continuing connection to land, water and community and we pay our respects to Elders past and present.
ASHM Health | ABN 48 264 545 457 | CFN 17788 | Copyright © 2024 ASHM
ASHM Health | ABN 48 264 545 457 | CFN 17788 | Copyright © 2022 ASHM